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While the UPR initially enhances proteasome activity to manage misfolded proteins, chronic ER stress can overwhelm the UPS, compromise proteasome function and exacerbate cellular dysfunction

doi: 10.1186/ar2165 91 IshiiKAFumotoTIwaiKTakeshitaSItoMShimohataNet al

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When the extracellular glutamine level is limited, some cancer cell lines are able to induce GS expression in order to escape from glutamine deficient-induced cell death

It decreases the migration of these cells from the peripheral blood because it has an anti-inflammatory action (Houghton et al., 1995) by suppressing the production of tumor necrosis factor alpha and interleukin 6 (Jaswal, et al., 2022) and decreasing the transcription level of cyclooxygenase-2 (Taka et al., 2015) and prevents biosynthesis of inflammatory mediators (Shaterzadeh-Yazdi et al., 2018)